Scientists win 2015 Nobel Prize for Chemistry
According to the Royal Swedish Academy of Sciences, the 2015
Nobel Prize for chemistry has been jointly awarded to three scientists for
their "mechanistic studies of DNA repair".
Tomas Lindahl, Paul Modrich and Aziz Sancar won "for
having mapped, at a molecular level, how cells repair damaged DNA and safeguard
the genetic information.Their work has provided fundamental knowledge of how a
living cell functions and is, for instance, used for the development of new
cancer treatments," the academy said.
Lindahl, a Swedish scientist, showed that "DNA decays
at a rate that ought to have made the development of life on Earth impossible. This
insight led him to discover a molecular machinery, base excision repair, which
constantly counteracts the collapse of our DNA", the academy stated.
Modrich, an American, showed how a cell corrects errors that
occur when DNA is replicated during cell division. "This mechanism,
mismatch repair, reduces the error frequency during DNA replication by about a
thousandfold," the academy said. Congenital defects in mismatch repair are
known, for example, to cause a hereditary variant of colon cancer."
Sancar, a U.S. and Turkish citizen, mapped nucleotide
excision repair - the mechanism that cells use to repair UV damage to DNA, the
academy said. "People born with defects in this repair system will develop
skin cancer if they are exposed to sunlight, it said.
Last year, two Americans and a German,Eric Betzig, Stefan W.
Hell and William E. Moerner, won the chemistry prize for their work on optical
microscopy, which opened up how molecules work close up.
Since 1901, the committee has handed out the Nobel Prize in
chemistry 107 times. In certain years, mainly during World Wars I and II, no
prize in chemistry was awarded.
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